The current COVID-19 pandemic is putting an enormous pressure not just in the society but also in all the scientific community.

If we want to follow a scientific approach to respond to the doubts and challenges that were generated, we need to find a balance between the most robust data, the best experimental methodologies to address the new problems and all the uncertainty associated.

In this presentation we will try to address this balance between best available data, clinical research methodology and uncertainty applied to what we know about pandemics, vaccine development and clinical trials. There will be a particular focus on the COVID-19 pandemic data and current research efforts for the development of vaccines and efficacious treatments.